منابع مشابه
Genomic insights into positive selection.
The traditional way of identifying targets of adaptive evolution has been to study a few loci that one hypothesizes a priori to have been under selection. This approach is complicated because of the confounding effects that population demographic history and selection have on patterns of DNA sequence variation. In principle, multilocus analyses can facilitate robust inferences of selection at i...
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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is frequently impervious to curative treatment efforts. Similar to other cancers associated with prolonged exposure to carcinogens, HNSCCs often have a high burden of mutations, contributing to substantial inter- and intra-tumor heterogeneity. The heterogeneity of this malignancy is further increased by ...
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Stephen M. J. Pollo, Abigail A. Adebusuyi, Timothy J. Straub, Julia M. Foght, Olga 4 Zhaxybayeva and Camilla L. Nesbø 5 Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada 6 Department of Biological Sciences, Dartmouth College, Hanover, NH, USA 7 Department of Computer Science, Dartmouth College, Hanover, NH, USA 8 Centre for Ecological and Evolutionary Synthesis...
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Alcohol "sensitivity" has been proposed as a predictive factor for development of alcohol dependence (Schuckit et al., 2005). Most measures of alcohol sensitivity in humans and animals include a component that can be ascribed to acute functional tolerance (AFT). AFT is a form of tolerance that develops within a single period of alcohol exposure and has a genetic component. We used microarray te...
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Mycobacterium simiae (Karassova V, Weissfeiler J, Kraszanay E, Acta Microbiol Acad Sci Hung 12:275-82, 1965) is a slow-growing nontuberculous Mycobacterium species found in environmental niches, and recently evidenced as an opportunistic Human pathogen. We report here the genome of a clinical isolate of M. simiae (MsiGto) obtained from a patient in Guanajuato, Mexico. With a size of 6,684,413 b...
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ژورنال
عنوان ژورنال: Microbiology and Molecular Biology Reviews
سال: 2010
ISSN: 1092-2172,1098-5557
DOI: 10.1128/mmbr.00004-10